This project has three main aims. First, we aim to validate and improve our ML models across different hospital networks and populations. Second, we aim to integrate ML models in different hospital information systems and evaluate their impact on daily hospital routine. Third, building upon these validated models, we aim to address effective risk communication strategies in order to effect behavioural changes in patients. Therefore, our project makes a fundamental contribution towards employing innovative personalized risk prediction and to assess its clinical implementation in a transnational context.